Dietary Amino Acid Source Elicits Sex‐Specific Metabolic Response to Diet‐Induced NAFLD in Mice - Transcriptomic impact of Xenobiotics
Article Dans Une Revue Molecular Nutrition and Food Research Année : 2023

Dietary Amino Acid Source Elicits Sex‐Specific Metabolic Response to Diet‐Induced NAFLD in Mice

Jelskey Gomez
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Yannick Lippi
Anne Fougerat
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Résumé

Scope: Non-alcoholic fatty liver disease (NAFLD) is a sexually dimorphic disease influenced by dietary factors. Here, the metabolic and hepatic effects of dietary amino acid (AA) source is assessed in Western diet (WD)-induced NAFLD in male and female mice. Methods and results: The AA source is either casein or a free AA mixture mimicking the composition of casein. As expected, males fed a casein-based WD display glucose intolerance, fasting hyperglycemia, and insulin-resistance and develop NAFLD associated with changes in hepatic gene expression and microbiota dysbiosis. In contrast, males fed the AA-based WD show no steatosis, a similar gene expression profile as males fed a control diet, and a distinct microbiota composition compared to males fed a casein-based WD. Females are protected against WD-induced liver damage, hepatic gene expression, and gut microbiota changes regardless of the AA source. Conclusions: Free dietary AA intake prevents the unhealthy metabolic outcomes of a WD preferentially in male mice.
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hal-04287354 , version 1 (15-11-2023)

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Clémence Rives, Céline Marie Pauline Martin, Lauris Evariste, Arnaud Polizzi, Marine Huillet, et al.. Dietary Amino Acid Source Elicits Sex‐Specific Metabolic Response to Diet‐Induced NAFLD in Mice. Molecular Nutrition and Food Research, 2023, ⟨10.1002/mnfr.202300491⟩. ⟨hal-04287354⟩
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